Optimise the freezing and lyophilisation of your APIs with Lyophitech
In the development and production of active pharmaceutical ingredients (APIs), every drying stage directly influences the quality, stability and value of your product.
Whether your API is derived from chemical synthesis, biotechnology, fermentation, chromatography or plant extraction, Lyophitech’s technologies enable you to develop more robust, faster and safer processes whilst preserving the critical characteristics of your molecules.
Why do API developers choose Lyophitech?
Because we do more than just supply freeze-drying equipment.
We provide a comprehensive platform that enables you to:
Develop a process using just a few grams of material thanks to the MiniDyn;
Understand and control the phenomena of deep-freezing prior to freeze-drying;
Accelerate development and scale-up;
Preserve the most fragile molecules;
Efficiently process highly diluted, high-value-added products;
Design bespoke systems tailored to each API;
Rapidly scale up to industrial production using robust, reproducible and high-performance processes.
Lyophitech transforms freezing and freeze-drying into genuine drivers of innovation for the development and production of active pharmaceutical ingredients.
Why choose our solutions?
Excellence in stability and preservation
Our rapid freezing and dynamic freeze-drying technologies minimise physical and chemical degradation to preserve the integrity, activity and stability of even your most sensitive APIs.
Cycle optimisation
Reduce your development and production times thanks to cycles optimised for each product, with controlled energy consumption and improved industrial productivity.
Bulk production
Designed for bulk freeze-drying, our equipment ensures excellent batch homogeneity whilst simplifying loading and unloading operations.
Industrial integration
Our solutions integrate easily into your production environment and adapt to your development, scale-up and industrialisation requirements.
Preservation of sensitive molecules
Protect APIs that are sensitive to heat, oxygen or mechanical stress using a gentle process that minimises oxidation, denaturation and degradation.
Expertise in biotechnology and fine chemicals
Our processes are particularly well-suited to APIs derived from:
fermentation,
chromatographic purification,
biotechnology,
complex chemical synthesis.
They ensure uniform drying whilst preserving the molecule’s critical properties.
Solvent removal and residue control
Our technologies facilitate the removal of solvents
Our technologies facilitate the removal of organic and aqueous solvents whilst controlling residual levels in accordance with pharmaceutical development requirements.
Safety and containment
Our equipment addresses the growing challenges associated with highly active APIs:
powder containment,
reduction of operator exposure,
automation of handling processes,
minimisation of cross-contamination.
It is particularly well-suited to environments handling high-value-added or highly toxic molecules (EPO).
Plant-based APIs and natural molecules
Plant extracts are often highly sensitive to heat and oxidation.
Our processes enable low-temperature drying whilst preserving the potency of the extracts, the compounds of interest and the functional properties of the natural active ingredients.
Reliability and repeatability
Precise control of sublimation conditions ensures excellent cycle reproducibility, without local overheating or batch-to-batch variability.
Automation to boost your productivity
Our equipment is designed to reduce downtime, minimise the need for human intervention and deliver lasting improvements to your industrial performance.
Rapid loading and unloading
Automated operations are completed in under 30 minutes to minimise downtime and improve equipment utilisation rates.
Fully contained processes
Product transfer takes place without exposure to ambient air, minimising oxidation and the risk of contamination.
Safe processes
The containment of operations, combined with CIP/NEP and SIP/SEP systems, facilitates cleaning whilst protecting both operators and products.
Intelligent automation
Advanced monitoring enables a single team to operate multiple installations simultaneously and optimise operating costs.
Off-peak operation
Separating the flash-freezing and freeze-drying stages allows the next batch to be prepared whilst another is undergoing sublimation, significantly increasing production throughput without additional investment.
A real impact on your industrial process
Thanks to Lyophitech’s technologies, ultra-rapid freezing and freeze-drying become genuine drivers of industrial performance.
In particular, our solutions enable you to:
Preserve the most sensitive molecules;
Accelerate development and scale-up;
Improve batch homogeneity and reproducibility;
Facilitate solvent removal;
Reduce operating costs;
Enhance operator safety;
Automate critical operations;
Effectively industrialise both conventional APIs and next-generation molecules.